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Journal of Nutrition Vol. 66 No. 3 November 1958, pp. 321-332
Copyright © 1958 by American Society for Nutrition
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Effect of Feeding Low Levels of Diethylstilbestrol on Gestation and Lactation of Rats1,2,

C. B. Browning, D. B. Parrish and F. C. Fountaine

Kansas Agricultural Experiment Station, Manhattan

Nineteen adult female albino rats and their litters (168 pups) were used to study some of the effects of feeding low levels of DES (0.6, 1.1, or 2.2 µg/100 gm body weight/day) for three days prior to breeding, and during gestation and lactation.

The feeding of DES did not appear to have a measurable effect on conception or gestation. However, growth of the young of lactating rats receiving DES in their rations was retarded significantly (P < 0.01), indicating decreased lactation by females receiving food containing DES. Uteri of weanling females from treated dams were not stimulated, as judged by the uterine-weight-response method, indicating that estrogens were not excreted via the mammary gland in detectable quantities.

Although there was a trend toward decreased total food intake by rats receiving DES during gestation and lactation, food intake apparently was sufficient for lactation, since all lactating females gained weight.

1 Contribution no. 569, Department of Chemistry and no. 263, Department of Dairy Husbandry, Kansas Agricultural Experiment Station. These data are to be submitted as a part of a thesis by the senior author to the Graduate School of Kansas State College of Agriculture and Applied Science, in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Animal Nutrition.

2 The authors express their appreciation to H. T. Gier and E. H. Herrick, Department of Zoology, for assistance during this study.

Manuscript received 22 May 1958.




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