QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Baldridge, R. C. Search for Related Content PubMed PubMed Citation Articles by Baldridge, R. C.

Effects of Thiamine and Riboflavin Deficiency on Histidine Metabolism^{1, 2,}

Department of Physiological Chemistry, Temple University School of Medicine, Philadelphia, Pennsylvania

1. Levels of histidase were considerably greater (difference significant at a probability level of less than 1%) and of urocanase somewhat greater (difference significant at a probability level of between 5 and 1%) in livers of thiamine-deficient compared with those of pair-fed control rats. Liver rhodanese levels were the same in both groups.

2. Liver histidase, urocanase and rhodanese levels were not affected by lack of dietary riboflavin in the rat.

3. It is suggested that the observed increase in histidase activity during thiamine deficiency may represent a metabolic adaptation to denial of an alternate pathway for the degradation of histidine.

² Supported in part by a grant from the National Institutes of Health, United States Public Health Service (Grant no. A-650-C3).

Manuscript received 3 April 1958.