QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hartsook, E. W. Articles by French, C. E. Search for Related Content PubMed PubMed Citation Articles by Hartsook, E. W. Articles by French, C. E.

A Study of the Effect of Deoxypyridoxine or Isoniazid upon Mineral Retention and Liver Enzyme Activities of Pyridoxine-Deficient Male Rats¹

Department of Animal Nutrition, The Pennsylvania State University, University Park

Based upon the responses (growth rate, hepatic glutamic-aspartic transaminase and cysteine desulfhydrase activities, and retention of dietary Ca, Mg, Na and K) of 15 groups of 4 rats fed a pyridoxine-free basal diet or the same plus either deoxypyridoxine (DOP), isoniazid (INH), or pyridoxine, the following conclusions seem warranted:

1. Under moderate pyridoxine depletion hepatic glutamic-aspartic transaminase activity appears to be reduced. Treatment with DOP, but not INH, appears to reduce such activity further. Under the same conditions hepatic cysteine desulfhydrase activity appears to be reduced below that of rats receiving complete diets and also appears not be reduced further by treatment with DOP or INH.

2. Under severe pyridoxine depletion the hepatic glutamic-aspartic transaminase and cysteine desulfhydrase activities are reduced significantly. The addition of INH to pyridoxine-deficient diets does not reduce the activities of these enzymes to any significant degree.

3. Calcium and Mg retention are not altered significantly in moderate or severe pyridoxine depletion. Under moderate pyridoxine depletion neither Na or K retention is reduced significantly. However, when DOP is given the retention of K, but not of Na, is reduced significantly. Under severe pyridoxine depletion the retention of both Na and K are reduced significantly. The addition of INH to pyridoxine-deficient diets does not reduce the retention of these minerals to any significant extent.

² Present Address: United Nations Children's Fund, United Nations, N. Y.

Manuscript received 20 March 1958.