QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Vogel, G. R. Articles by Andrews, F. N. Search for Related Content PubMed PubMed Citation Articles by Vogel, G. R. Articles by Andrews, F. N.

Effect of Thyroprotein and Penicillin on the Thiamine Requirement and Growth of Normal and Hyperthyroid Rats¹

Departments of Biochemistry and Animal Husbandry, Purdue University, Lafayette, Indiana

A series of experiments was conducted to determine the effect of dietary procaine penicillin G and thyroprotein on the thiamine requirements, growth at high levels of vitamins, and food efficiency of albino rats. The effects of thyroprotein on these factors were overcome in all cases by the addition of the antibiotic to the ration. Penicillin decreased the thiamine requirements and increased growth as well as food efficiency at high vitamin levels. These effects were directly proportional to the level of thyroprotein in the ration.

Subsequent experiments, in which protein-bound iodine was determined after various antibiotic treatments, revealed no significant changes in blood thyroidal activity (organic iodine).

² Deceased November 26, 1957.

Manuscript received 11 March 1958.