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Journal of Nutrition Vol. 65 No. 3 July 1958, pp. 397-407
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Effect of Certain Necrosis-Preventing Factors on Hemolysis in Vitamin E-Deficient Rats and Chicks1

C. Gitler2, M. L. Sunde and C. A. Baumann

Departments of Biochemistry and Poultry Husbandry, College of Agriculture, University of Wisconsin, Madison

The rate of depletion of vitamin E in rats and chicks was followed by determining the sensitivity of the erythrocytes to the hemolyzing action of dialuric acid in vitro. This rate was not affected by replacing dietary casein with either brewers' or torula yeast up to levels as high as 60% of yeast. Selenium, methionine, cystine, methylene blue and 2,6-ditertiarybutyl-4-methylphenol (BHT) did not alter the rate of hemolysis under the conditions employed. However, N-N'-diphenyl-p-phenylenediamine (DPPD) prevented or minimized hemolysis even when the rats had been depleted of vitamin E for long periods of time. These results are contrasted to the activities of these compounds against liver necrosis.

Preliminary experiments showed that hemolysis may also be used as an indication of vitamin E-depletion in chicks.

1 Published with the approval of the Director of the Wisconsin State Agricultural Experiment Station. Supported in part by grants from the Sulphite Pulp Manufacturers' Research League, Inc., Appleton, Wisconsin, and from the Wisconsin Alumni Research Foundation.

2 Present address: Instituto Nacional de la Nutricion, Mexico, D. F., Mexico.

Manuscript received 31 January 1958.




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