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Behavioral Changes in Rats and Guinea Pigs Induced by the Administration of Indole 3-Acetic Acid and 6-Aminonicotinamide

Thudichum Psychiatric Research Laboratory, Galesburg State Research Hospital, Galesburg, Illinois

The daily feeding of 1 to 5 mg amounts of indole 3-acetic acid (I3-AA) was found to produce definite changes in the behavior of rats within a minimum period of 5 weeks. The changes were characterized by lassitude, intractability on handling and a disregard for foreign objects introduced into their cages. These changes were found to be apparently irreversible in a majority of the affected rats after 10 weeks. At no time was there any weight loss.

The injection of I3-AA subcutaneously in guinea pigs produced a significant loss of righting reflex.

A similar affect was produced in guinea pigs by the injection of 6-aminonicotinamide when the animals were protected by an adequate amount of niacinamide.

² Present address: The Quaker Oats Company Research Laboratories, Barrington, Illinois.

Manuscript received 12 August 1957.