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Journal of Nutrition Vol. 64 No. 1 January 1958, pp. 127-136
Copyright © 1958 by American Society for Nutrition
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The Effect of Ethionine Feeding on Liver and Kidney Coenzyme a Content in the Rat1

Alvin S. Wenneker2 and Lillian Recant

Nutrition Research Laboratory, Department of Preventive Medicine, Washington University School of Medicine, St. Louis, Mo.

Coenzyme A concentration and total hepatic coenzyme A content were found to be decreased in rats chronically fed ethionine compared to values obtained in pair-and ad libitumfed controls.

Total renal coenzyme A content in ethionine-fed rats was slightly, but significantly, increased over that of pair-fed controls.

It is postulated that ethionine may impair coenzyme A synthesis as a consequence of its metabolic antagonism to methionine.

1 Supported in part by a grant from the Nutrition Foundation and the National Institutes of Health, Division of Arthritis and Metabolic Diseases.

2 Fellow of the National Foundation for Infantile Paralysis.

Manuscript received 31 July 1957.




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