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The Effect of Thyroid Activity on the Conversion of Carotene and Retinene to Vitamin A and on Serum Proteins

Department of Biochemistry, Indian Institute of Science, Bangalore, India

The effect of iodinated casein, thiourea and thiouracil on retinene and carotene metabolism in rats has been investigated.

Iodinated casein decreased whereas thiourea increased the liver storage of vitamin A on feeding retinene, but thiouracil did not show any significant effect. There was no significant difference in total vitamin A in livers between the iodinated casein and thiourea groups, when retinene was injected intravenously. On feeding carotene, hyperthyroid rats stored more and hypothyroid rats less vitamin A in the liver than the controls.

The changes occurring in the different components of serum proteins, in vitamin A-deficient, hyperthyroid and hypothyroid rats have been shown. In vitamin A deficiency a very low albumin level and a significant increase in ₂-, ß₂- and -globulin levels are observed. In hyperthyroidism, there is a decrease in the albumin and an increase in the ₂- and ß₂-globulins. In hypothyroidism an increase in the ₁-globulin is noted.