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The Effects of Biologically Unavailable Lysine (Heated Casein) on Growth

I. Body Weight and Bone Growth

Division of Dental Research, Faculty of Medicine, Columbia University, New York, N. Y.

1. A temporary growth cessation, expressed in lowered body weight (allowing of endochondral bone formation) takes place in animals fed adequate diets in which the sole source of protein is heated casein.

2. The imbalance produced by the diet induces a uniform retardation in the formation of both skeletal and soft structures, under the conditions in which this experiment was carried out.

3. The changes occurring during the period of retardation are reversible and self-correcting without supplementation of the diet.

Manuscript received 30 July 1956.