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Vitamin E Deficiency in the Monkey

II. Tissue Concentrations of Nucleic Acids and Creatine¹

Department of Biochemistry, School of Medicine, University of Arkansas, Little Rock

The concentrations of tissue nucleic acids and muscle creatine were determined on vitamin E-deficient, normal, and recovered monkeys. Vitamin E deficiency resulted in an elevated concentration of skeletal muscle desoxyribonucleic acid (DNA) and an elevated concentration of bone marrow DNA and ribonucleic acid (RNA). The bone marrow RNA/DNA ratio was elevated in vitamin E-deficient monkeys. All these changes were reversed with tocopherol therapy. Skeletal muscle creatine was reduced in vitamin E-deficient monkeys and only partially restored toward normal in recovered animals.

² Studies carried out during the tenure of a Lederle Medical Faculty Award.

Manuscript received 17 June 1957.