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Effect of Vitamin B₁₂ and Aureomycin Supplements on Vitamin B₁₂ Liver Stores and on the Development of Anemia in Gastrectomized Rats^1,2,

Departments of Home Economics and Physiological Chemistry, University of California, and the Veterans Administration Center, Los Angeles

Ninety days after operation, the vitamin B₁₂ liver content of gastrectomized rats was found to be greatly reduced when compared to that of non-operated animals. The moderate anemia present in the gastrectomized animals could not be corrected by giving vitamin B₁₂ either orally or by injection. Vitamin B₁₂ administered in conjunction with folic acid or a hog stomach preparation as a source of intrinsic factor likewise had no effect in preventing the development of the anemia. However, hemoglobin values were found to be within the normal range in gastrectomized rats fed a supplement of Aureomycin. There was no apparent increase in vitamin B₁₂ liver stores of the antibiotic-fed gastrectomized animals.

² Supported in part by grants from the Upjohn Company, Kalamazoo, Michigan, and Organon, Inc., Orange, New Jersey.

³ Present address: Veterans Administration Hospital, Syracuse, New York.

Manuscript received 4 March 1957.