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Journal of Nutrition Vol. 61 No. 3 March 1957, pp. 421-436
Copyright © 1957 by American Society for Nutrition
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A Comparative Study of Thiamine-sparing Agents in the Rat

E. M. Scott and Isabelle V. Griffith

Arctic Health Research Center, Public Health Service, Department of Health, Education, and Welfare Anchorage, Alaska

The effects of thiamine, fat, protein, penicillin and ascorbic acid, singly and in combination in the diet, on the growth of rats were studied. The effects of these agents on thiamine concentration of tissues were determined.

Fat or protein, penicillin, and ascorbic acid were effective sparing agents in combination. Penicillin plus streptomycin or aureomycin was no more effective than penicillin alone.

All 4 sparing agents increased the thiamine content of the animals in approximate proportion to their effects on growth.


Manuscript received 17 September 1956.





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