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Journal of Nutrition Vol. 61 No. 3 March 1957, pp. 389-394
Copyright © 1957 by American Society for Nutrition
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The Influence of Ascorbic Acid Deficiency in Guinea Pigs on the Synthesis of Purines, Serine, and Methionine1

James S. Dinning2, Kingsley W. Cosgrove, Jr. and Paul L. Day

Department of Biochemistry, School of Medicine, University of Arkansas, Little Rock

Ascorbic acid deficiency in guinea pigs resulted in a reduced utilization of formate in the synthesis of serine and methionine by liver homogenates. The deficiency did not affect the incorporation of formate into purines, either when the formate was incubated with tissue homogenates or injected into the animal.

1 This investigation was supported by research grant no. A-721 from the National Institutes of Health, Public Health Service.

2 These studies were carried out during the tenure of a Lederle Medical Faculty Award.

Manuscript received 28 September 1956.




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