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The Effect of Withdrawal of Estrogens on the Nitrogen, Calcium and Phosphorus Balances of Women^{1, 2,}

Committee on Home Economics and the Chicago Lying-in Hospital, University of Chicago, Chicago, Illinois

1. The effect of withdrawal of diethylstilbestrol therapy in two oophorectomized subjects and of oophorectomy in one subject on the nitrogen, calcium, phosphorus balances and on the urinary 17-ketosteroid, pregnanediol, and corticoid excretions was investigated.

2. For each subject there was a slight increase in nitrogen excretion upon withdrawal either of diethylstilbestrol or of natural estrogens. Two of the subjects exhibited excretions increased to an extent to justify the conclusion that in these subjects at a given level of nitrogen intake, withdrawal of estrogenic influences may have been responsible for the increased nitrogen loss.

3. With calcium intakes of 250 to 350 mg per day, the three subjects showed negative calcium balances that were significantly increased after withdrawal of estrogens. It appears that cessation of the estrogenic effect resulted in an increased calcium output, urinary excretion being the chief pathway for the loss of the mineral in one subject (A) and urinary and fecal excretion being jointly responsible in subjects B and C.

4. For one subject (A), the phosphorus balances during the two periods of study paralleled the calcium balances, becoming increasingly negative in the period without diethyl-stilbestrol. The phosphorus balances of the other two subjects did not follow this direction.

5. The 17-ketosteroid and pregnanediol values were in the normal range for all periods studied. Subjects A and B appeared to have depressed urinary corticoid values while on diethylstilbestrol therapy.

² Submitted by the senior author in partial fulfillment of the requirements for the degree of Doctor of Philosophy, University of Chicago.

³ Present address: Home Economics Research Branch, Agricultural Research Service, United States Department of Agriculture, Washington, D. C.

⁴ Present address: Dean, College of Home Economics, Michigan State University, East Lansing, Michigan.

Manuscript received 12 July 1956.