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Journal of Nutrition Vol. 61 No. 2 February 1957, pp. 207-217
Copyright © 1957 by American Society for Nutrition
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Investigations on the Metabolism of Fluoride

IV. Fluoride Balance Studies at High Levels of Intake in Rabbits1

Dwight E. Gardner, Thomas G. Scharff, Frank A. Smith and Harold C. Hodge

Division of Pharmacology and Toxicology, Department of Radiation Biology, School of Medicine and Dentistry, University of Rochester, Rochester, New York

Fuoride intake and excretion were measured in rabbits given drinking water containing from 0 to 150 ppm of fluoride over a 19-day period. About half of the ingested fluorides were retained, viz., positive balances averaged 51% of the ingested fluoride. An average of 76.5% of the absorbed fluoride was retained, presumably in the skeleton. More fluoride was excreted in the feces than in the urine. However, urinary excretion of fluoride increased in proportion to the increase in water fluoride concentration, the fluoride content of the food being constant. A nomograph has been constructed for the interconversion of ingestion, absorption, retention, and urinary excretion data. Data from literature sources tested on the nomograph agreed well with those obtained in this experiment.

1 This paper is based on work performed in part under contract with the United States Atomic Energy Commission at the University of Rochester Atomic Energy Project, Rochester, New York, and supported in part by a grant from the E. I. duPont de Nemours and Co.

Manuscript received 29 August 1956.




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