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Pantothenic Acid Deficiency and Hypophysectomy¹

Yale Nutrition Laboratory, Department of Biochemistry, Yale University School of Medicine, New Haven, Connecticut

The influence of pantothenic acid and growth hormone on the growth process has been investigated in young hypophysectomized rats. With hypophysectomized rats, whether or not they received pantothenic acid, growth hormone induced a marked growth response; the growth rate of the deficient group was about one half of that of the control. With rats not receiving growth hormone, pantothenic acid-fed animals demonstrated only a slight weight increase, while pantothenic acid-deficient animals failed to gain weight.

Pantothenic acid-deficient, growth hormone-injected rats frequently had congested and hemorrhagic adrenal cortices. The histological study of the adrenals of the three other groups revealed only the adrenal glands that might be expected after hypophysectomy. The relation of growth hormone and pantothenic acid under these experimental conditions is discussed.

Manuscript received 13 July 1956.