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Resistance of Mouse Tissue Sulfhydryl to Alterations by Changes in Dietary Intake of Sulfur Amino Acids¹

Department of Physiology and Pharmacology, School of Medicine, University of Pittsburgh, Pittsburgh, Pa.

The only appreciable change in mouse tissue sulfhydryl concentration found to occur in association with alteration in dietary content of sulfur amino acids was a marked decrease in liver non-protein sulfhydryl, occurring in association with use of diets deficient in sulfur amino acids.

In rat weanlings, a marked decrease in liver non-protein sulfhydryl occurred in association with a dietary lack of sulfur amino acids, but not with a lack of valine, of isoleucine, or of threonine.

Mice placed on sulfur amino acid-deficient diets which were effective in markedly decreasing liver non-protein sulfhydryl, exhibited susceptibilities to semi-lethal x-irradiation indistinguishable from those exhibited by mice maintaned on diets adequate in sulfur amino acid content.

Manuscript received 25 February 1956.