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Effect of Added Lysine on Growth of Rats Fed a Cereal and Milk Diet

Mead Johnson Research Laboratories, Evansville, Indiana

The gain in weight of male weanling rats on a diet of 70% cereal and 30% powdered whole milk was not significantly increased by the addition to the diet of 0.14 or 0.28% of L-lysine (equivalent to 0.2 or 0.4% of L-lysine added to the cereal). Addition of a supplementary vitamin mixture had no significant effect on weight gain with or without added lysine in the diet.

The diet of 70% cereal and 30% powdered milk contained approximately 1.08% lysine, which exceeds the requirement for growth, 1%, found by Rose ('37). A mixture of 61% cereal and 39% powdered milk (which is equivalent to one part cereal and 5 parts fluid milk such as used in infant feeding) contains approximately 1.2% lysine.

On the diet of 70% cereal and 30% powdered milk rats grew as well as they do on stock diets or on good experimental diets used in these laboratories. From the data on food intake during the growth period it has been calculated that the daily lysine intake decreased from about 1275 mg per kilogram of body weight during the first week after weaning (average midweek weight, 65 gm) to about 725 mg per kilogram during the 6th week (average midweek weight, 230 gm).