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The Influence of Amino Acids and other Organic Compounds on the Gatrointestinal Absorption of Calcium⁴⁵ and Strontium⁸⁹ in the Rat

Two Figures

Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee^,2

1. Eighteen amino acids, including those essential for the rat, were assayed for effect on the gastrointestinal absorption of Ca⁴⁵ and Sr⁸⁹. The minerals and amino acid were ingested simultaneously; radioassay values for the femur obtained 24 hours after dosage were used as a measure of absorption.

2. L-Lysine and L-arginine were the most potent in promoting mineral absorption, approximately doubling the Ca⁴⁵ and Sr⁸⁹ found in the femurs. L-Tryptophan, L-leucine, and L-aspartic acid also produced notable increases. The other amino acids were less effective or ineffective.

3. Lactose produced a greater response than L-lysine and L-arginine. The latter two were more effective in promoting mineral absorption than either gluconate, lactate, citrate, or a mixture of B vitamins.

4. Injection of Ca⁴⁵ and Sr⁸⁹ into lysine-treated rats resulted in no increase in radioactivity in the femur while ingestion of both the minerals and lysine produced the usual twofold increase in femur values.

5. The rat preferentially absorbed Ca⁴⁵ over Sr⁸⁹ by a factor of about 1.7.

6. Analysis of the Ca*/Sr* ratios in the femurs revealed that most substances were slightly more effective in promoting Sr⁸⁹ absorption than Ca⁴⁵ absorption.

7. A dose-response curve of lysine versus femur Ca⁴⁵ and Sr⁸⁹ values showed that a molar ratio of lysine:CaCl₂ between 1 and 2 was necessary for significant increases in mineral absorption.

8. These findings were discussed in terms of possible mechanisms of action for the stimulatory amino acids.

² Under contract with the United States Atomic Energy Commission.

Manuscript received 20 February 1956.

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