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Journal of Nutrition Vol. 59 No. 3 July 1956, pp. 327-336
Copyright © 1956 by American Society for Nutrition
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The Biological Utilization of the Palmitic Acid Esters of Pantothenic Acid1

Taketami Sakuragi and Fred A. Kummerow

Department of Food Technology, University of Illinois, Urbana

The biological utilization of fat-soluble derivatives of pantothenic acid, ethyl dipalmitoxypantothenate and ethyl 2'-monopalmitoxypantothenate was compared with that of calcium pantothenate in rats. The over-all activity of the palmitic acid esters was equal to that of the water-soluble form as a supplement for pantothenic acid; this was proved by feeding experiments under various conditions. When a large single dose of the preparation was administered to the rats, the excretion of the pantothenic acid into the urine was markedly increased by esterifying the vitamin with one or two moles of palmitic acid. The biological utilization of the pantothenic acid moiety when present as an ester appeared to be slower than that of the free vitamin. The liver of pantothenatedeficient rats, however, contained a normal pantothenate level within two hours after the administration of ethyl dipalmitoxypantothenate. The activity of pantothenyl tripalmitate was found to be equal to that of free pantothenol.

1 This work was supported by research grant no. A-257 from the National Institutes of Health, U. S. Public Health Service, Department of Health, Education and Welfare.

Manuscript received 12 January 1956.




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