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Further Studies on the Effect of Aureomycin on the Apparent Utilization of Vitamin A by the Rat

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Food and Drug Laboratories, Department of National Health and Welfare, Ottawa, Canada

Further evidence has been obtained which indicates that aureomycin does not exert its effect on the vaginal smear assay for vitamin A by increasing the absorption of the dose. It has been shown that the intestinal contents are free of vitamin A during the period in which aureomycin is effective. Furthermore, aureomycin increased the response to subcutaneous doses of vitamin A even though no part of these doses appeared in the intestinal contents or wall.

Aureomycin had no effect on the utilization of vitamin A when ascorbic acid or folic acid were added to the diet, or when sucrose was substituted for starch. Possible mechanisms of the action of aureomycin are discussed.