QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zucker, T. F. Articles by Seronde, J. Search for Related Content PubMed PubMed Citation Articles by Zucker, T. F. Articles by Seronde, J., Jr.

Antibody Formation and Natural Resistance in Nutritional Deficiencies¹

Department of Pathology, Columbia University, New York, N. Y.

Joseph Seronde, Jr.

Laboratory of Comparative Pathology, Maynard, Mass., and Department of Pathology, Boston University School of Medicine Boston, Mass.

A vaccine prepared from killed cultures of Corynebacterium kutscheri, strain 197, has been administered to rats with variious dietary deficiencies: calories, thiamine, pyridoxine and pantothenic acid. With deficiencies of calories or thiamine, there is no significant reduction in ability to form agglutinins. No detectable agglutinins are formed in pyridoxine deficiency. In pantothenate deficiency, some animals lose their ability to form agglutinins while this capacity is impaired in others, resulting in a mean value between those for deficiencies of thiamine and pyridoxine.

Ability to make agglutinins is entirely unrelated to the degree of resistance to the live organism shown by rats on these various regimes. Therefore it is concluded that the resistance of the normal rat, which is lost in pantothenate deficiency, does not rest upon ability to form antibodies as typified by agglutinins.

Manuscript received 7 January 1956.