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Thiamine, Pyridoxine and Pantothenic Acid in the Natural Resistance of the Rat to a Corynebacterium Infection¹

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Laboratory of Comparative Pathology, Maynard, Mass., and Department of Pathology, Boston University School of Medicine, Boston, Mass.

Theodore F. Zucker and Lois M. Zucker

Department of Pathology, Columbia University, New York, N. Y.

A corynebacterium which produces spontaneous disease in young pantothenate-deficient rats failed to do so in similar animals deficient in either pyridoxine or thiamine, or in animals whose caloric intake was severely restricted. The disease does not appear in healthy rats on a complete diet.

Injected into animals on these various regimens, this organism caused fatal infection in all pantothenate-deficient rats of one strain, and in a relatively small percentage of pyridoxine- and thiamine-deficient rats. Another strain of rats on pantothenate deficiency proved more resistant. The complete diet, even when restricted in amount, protected the inoculated animal against serious infection.

Manuscript received 7 January 1956.