QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schaefer, A. E. Articles by Greene, R. D. Search for Related Content PubMed PubMed Citation Articles by Schaefer, A. E. Articles by Greene, R. D.

Absorption of Topically Applied Vitamins

Two Figures

The Squibb Institute for Medical Research, E. R. Squibb and Sons, Division of Olin Mathieson Chemical Corporation, New Brunswick, New Jersey

The absorption of topically applied vitamins by the rat has been determined. In view of the small doses of the vitamins (thiamine, riboflavin, pantothenic acid, pyridoxine and vitamin D) administered and the limited time allowed for absorption, the utilization of the vitamins studied is considered highly efficient. In addition to the body weight gain responses, and the prevention or cure of deficiency symptoms, the data on urinary excretion of thiamine and riboflavin substantiate the conclusion.

In general, a plasticized hydrocarbon water-absorbing gel ointment base was superior to a carbowax preparation as a vehicle for skin transfer of the vitamins studied. An alcoholic vanillin solution was also an effective vehicle for the skin absorption of riboflavin, pantothenic acid, pyridoxine and vitamin D.

Manuscript received 28 October 1955.