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Dental Caries in the Albino Rat in Relation to the Chemical Composition of the Teeth and of the Diet

II. Variations in the Ca/P Ratio of the Diet Induced by Changing the Phosphorus Content

Department of Physiology, Division of Basic Sciences in the Health Services, Emory University, Emory University, Georgia

Quadruplicate groups of litter mate albino rats were fed from weaning on cariogenic diets in which 4 different Ca/P ratios were tested; the ratio was changed by maintaining the calcium concentration at a constant level and varying the phosphorus.

In one experiment in which the animals were desalivated, there was a progressive decrease in the caries score as the Ca/P ratio was decreased from 1: 0.5 to 1: 2. Further decrease in the ratio to 1: 3 had no effect on the incidence or extent of caries.

In a second experiment in which the animals were not desalivated in order to avoid the complications of caries over the same feeding period, the nitrogen, calcium, phosphorus, magnesium, fluoride and CO₂ content of the teeth was the same on each of the 4 diets.

The effect of varying the Ca/P ratios of the diet on its cariogenicity was, therefore, not related to changes in the composition of the teeth.

This article has been cited by other articles:

				F. J. McClure Cariostatic Effect of Phosphates Science, June 12, 1964; 144(3624): 1337 - 1338. [Abstract] [PDF]