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A Study of the Relation Between the Liver Protein Regeneration Capacity and the Hepatic Necrogenic Activity of Yeast Proteins

Department of Biochemistry and Nutrition, School of Medicine, School of Tropical Medicine, University of Puerto Rico, San Juan

Liver protein regeneration and hepatic necrogenic activity of two different types of yeasts (a brewers' and a Torula yeast) have been studied. The results show a close parallelism between these two activities.

The Torula yeast was found to be necrogenic at both levels used (9 and 18% protein) and also was incapable of restoring liver protein in the depleted animals.

The brewers' yeast behaved similarly at the lower level but at the 18% protein level was found to be non-necrogenic and also capable of restoring maximum liver stores of protein in the depleted animals.

Both DL-methionine and L-cystine when fed at a 0.5% level together with the Torula yeast protected all of the animals from developing liver necrosis and also induced a complete regeneration of the liver protein in the depleted animals.

When both yeasts were fed together ( brewers' and Torula yeasts) full protection against liver necrosis as well as optimum liver protein regeneration was obtained.