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The Influence of Age and Diet on Ascorbic Acid Metabolism in Rats¹

Laboratory of Human Nutrition, School of Home Economics, University of Alabama, Tuscaloosa

Groups of male and female rats received ascorbic acid-deficient diets, and diets supplemented with ascorbic acid. The animals were sacrificed at 63 and 112 days; plasma, whole blood and white cell-platelets, liver, kidney, adrenals, ovaries and testes and urine were analyzed for ascorbic acid content.

Females in both age groups had significantly lower content of ascorbic acid in plasma, whole blood and platelets in both age groups, and a significantly lower content in the kidneys for both age groups.

Oral supplements of 50 mg daily of ascorbic acid for 21 days prior to death caused no increase in ascorbic acid content of blood or organs for either sex. Urinary excretion of ascorbic acid was increased for both sexes.

² Present address: Medical College of Alabama, Birmingham.

Manuscript received 1 August 1955.