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Studies of the Effects of Chlortetracycline, Vitamin E and Vitamin K in the Nutrition of the Rat

I. Growth

One Figure

Department of Veterinary Physiology and Pharmacology and the Department of Veterinary Pathology and Hygiene, College of Veterinary Medicine and Agricultural Experiment Station, University of Illinois, Urbana

A factorial design was used to ascertain the effects of vitamins E and K and chlortetracycline upon rats during their growth period. The variables were fed at levels of 0.02% or 0.03%. The addition of vitamin E or chlortetracycline to a vitamin-E-deficient diet increased growth significantly (1% level). There was some indication of an interaction of vitamins K and E. While the testicles of rats fed the basal ration showed severe degeneration on histopathological examinations, those of animals fed rations containing chlortetracycline, vitamin K or vitamin E showed no such degeneration. Vitamin E or chlortetracycline but not vitamin K increased the vitamin A concentration in the liver. Chlortetracycline reduced the number of the coliform and lactic acid bacteria. Vitamin K reduced the number of coliform bacteria. Chlortetracycline and vitamin K were conducive to the growth of yeast in the colon.