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Journal of Nutrition Vol. 57 No. 4 December 1955, pp. 541-554
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Experimental Obesity

I. Production of Obesity in Rats by Feeding High-Fat Diets

Three Figures

Olaf Mickelsen, Samuel Takahashi and Carl Craig1

Laboratory of Biochemistry and Nutrition, National Institute of Arthritis and Metabolic Diseases, U. S. Public Health Service, Department of Health, Education, and Welfare, Bethesda, Maryland

1. Obesity has been produced in normal male rats by the ad libitum feeding of a diet containing 63% of fat and adequate amounts of vitamins, minerals and protein.
2. When weanling rats were fed this diet, they gained weight at a higher rate than rats on our "best" low-fat or stock diets. Three strains of rats have shown the same response. The maximum weight attained on the high-fat diet was 1655 gm.
3. Approximately 70% of the weanling rats of the Osborne-Mendel strain randomly secured from the stock colony have attained weights over or close to 1000 gm when fed the high-fat diet. We believe that the obesity does not result from any genetic or hormonal distrubance.

1 Present address: Kirksville College of Osteopathy and Surgery, Kirksville, Mo.

Manuscript received 8 July 1955.


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