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Journal of Nutrition Vol. 57 No. 2 October 1955, pp. 287-295
Copyright © 1955 by American Society for Nutrition
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Effects of Octachloronaphthalene on Vitamin A Metabolism in the Rat1

Ruth E. Deadrick2, J. G. Bieri3 and R. R. Cardenas, Jr.

Department of Biochemistry and Nutrition, University of Texas Medical Branch, Galveston

The addition of 0.05 to 0.30% of octachloronapthalene to the diet of rats greatly accelerated the loss of vitamin A from the liver. There was no effect on the vitamin A or vitamin E in the blood, nor did the vitamin E in the liver change significantly. Utilization of injected carotene was not impaired by feeding octachloronaphthalene but a marked decrease in utilization occurred with carotene given per os.

Octachloronaphthalene in the diet caused the excretion in the feces of an unidentified yellow material.

The addition of 8% of brewers' yeast to a purified diet containing octachloronaphthalene prevented fatty infiltration in the liver, but did not eliminate the accompanying hypertrophy and lesions of that tissue.

1 These studies were aided by a contract between the Office of Naval Research, Department of the Navy, and the University of Texas, NR 123-118. A preliminary report of this work appeared in Fed. Proc., 14: 428 (1955).

2 Present address: Surgical Research Unit, Brooke Army Medical Center, Fort Sam Houston, Texas.

3 Present address: Nutrition Unit, National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda 14, Maryland.

Manuscript received 20 May 1955.




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