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Vitamin A Metabolism in Infection

Effect of Sterile Abscesses in the Rat on Serum and Tissue Vitamin A^1,2,

Department of Pediatric Research, Kunstadter Laboratories for Pediatric Research, Michael Reese Hospital and the Department of Pediatrics, Northwestern University Medical School, Chicago, Illinois

Sterile abscesses produced by single or multiple subcutaneous or intramuscular injections of turpentine or sweet almond oil in rats resulted in marked lowering of serum vitamin A concentrations. The liver vitamin A content and concentrations also decreased. The response to oral administration of test doses was, however, normal, and the liver concentrations of vitamin A after a large oral dose did not differ from the normal control animals given similar doses. Vitamin A concentrations in the centers and peripheries of abscesses did not differ from those of normal subcutaneous tissues. As a result of the abscesses, some loss of the vitamin A occurs through the urine. Speculations as to the possible significance of these findings are discussed.

² Presented before the 122nd Annual Meeting of the American Chemical Society, Atlantic City, New Jersey.

³ Present address: Department of Pediatrics, Cedars of Lebanon Hospital, 4833 Fountain Avenue, Los Angeles 29, California.

Manuscript received 13 September 1954.