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Effect of Riboflavin and Choline Deficiencies on Water Metabolism in Rats

Laboratory of Nutrition, Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel

1. Rats maintained on a diet deficient in riboflavin or in choline exhibit a delayed diuretic response to a water load.

2. In vitro experiments showed that the ability of the liver to inactivate pitressin is not impaired in riboflavin deficiency. Injection of cortisone or ACTH, which are without any effect on the diuresis of normal hydrated rats, increased urine excretion in deficient animals.

3. Livers of choline-deficient rats maintained on either a low- or high-fat diet, possess a diminished pitressin-inactivating ability. Caloric deficiency imposed on rats kept on a choline-deficient, high-fat diet reduced the fat content and simultaneously improved the pitressin-inactivating capacity of the liver. Vitamin B₁₂ and aureomycin likewise restored the impaired ability of the liver to destroy pitressin; they had, however, no lipotropic effect.