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The Fate of Urea in Growing Pigs^{1 ,2 ,3}

Iowa Agricultural Experimental Station and Institute of Atomic Research, Ames

This investigation was conducted to study the metabolism of urea in growing pigs using N¹⁵-labeled urea by oral administration in conjunction with a 13.3% protein ration. Six pigs were used. During the three days on experiment, 4 pigs received different amounts of N¹⁵-labeled urea while the two control pigs received regular urea. All 6 animals were sacrificed on the 4th day. The results of the determination of N¹⁵ in both the protein and non-protein nitrogen fractions of liver, kidneys and blood plasma; muscle protein nitrogen, urine and fecal nitrogen are presented. There is a small but definite amount of the administered urea incorporated into the body protein.

² After this manuscript was prepared, the following report appeared in abstract: Dekker, E. E., 1955, Urea as a source of nitrogen for biosynthesis of amino acids. Fed. Proc., 14: 201.

³ This investigation was supported in part by a research grant through Dr. James Waddell of the E. I. du Pont de Nemours and Company, Wilmington, Delaware.

Manuscript received 5 May 1955.