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The Pantothenic Acid Requirement of the Baby Pig¹

Michigan State College, East Lansing, Michigan

After an initial depletion-adjustment period, 62 selected baby pigs were individually fed a "synthetic" milk for an experimental period of 48 days.

The results show that the pantothenic acid requirement of the baby pig for optimum growth and feed efficiency approximates 12.5 mg of calcium pantothenate per kilogram of solids.

The baby pigs receiving the milk devoid of calcium pantothenate developed a severe diarrhea usually within two to 4 weeks. Locomotor incoordination developed in an additional 7 to 10 days if the pigs did not become so weakened that they died prior to this time.

Almost all of the baby pigs receiving suboptimal amounts of calcium pantothenate developed a severe diarrhea usually within two to 4 weeks. Locomotor incoordination developed in most cases within 4 to 7 weeks.

Pathological studies showed that lesions present in the large intestine and nervous system of pantothenic acid-deficient pigs were essentially those described by previous workers. The increase in the connective tissue of the submucosa was more marked in the case of pigs which had diarrhea for a long period of time. This tissue was still present in large amounts in the submucosa of deficient animals treated with calcium pantothenate. Myelin degeneration was still found in the sciatic nerve of treated animals. The glomerular layer of the adrenals of almost all pantothenic acid-deficient pigs was decreased in thicknes.

² The data contained in this paper are a portion of the research and thesis presented by the senior author in partial fulfillment of the requirements for the degree of Doctor of Philosophy, School of Graduate Studies, Michigan State College, East Lansing.

³ Departments of Animal Husbandry, Animal Pathology and Agricultural Chemistry, Michigan State College, East Lansing. This work was supported, in part, by a grant-in-aid from National Vitamin Foundation, Inc., New York, N. Y. The authors are indebted to Merck and Co., Inc., Rahway, New Jersey, and to Lederle Laboratories Division, Pearl River, N. Y., for the B vitamins used in this experiment.

Manuscript received 3 February 1955.

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