QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Murray, T. K. Articles by Campbell, J. A. Search for Related Content PubMed PubMed Citation Articles by Murray, T. K. Articles by Campbell, J. A.

Effect of Aureomycin on Liver Storage of Vitamin A, and on Growth, Depletion and Survival Time of Rats¹

Food and Drug Laboratories, Department of National Health and Welfare, Ottawa, Canada

The effects of aureomycin on storage of vitamin A and on growth, depletion rate and survival of rats, have been studied. The increase in liver stores when aureomycin was fed for 4 weeks was not significant. Liver and kidney stores were unaffected during depletion. Rate of depletion was decreased and weight at depletion increased by aureomycin. Survival time of rats on a "vitamin A-free" diet was variable but seemed to be increased by aureomycin in females. Growth rates of rats on low vitamin A intakes were increased by aureomycin but were not affected when adequate amounts of vitamin A were fed. Females stored vitamin A in their livers more efficiently than did males, lived longer on a "vitamin A-free" diet and maintained kidney stores longer than did males.

It is concluded that aureomycin makes available amounts of vitamin A which effect survival time and depletion time but which are not large enough to influence significantly the liver stores.

Manuscript received 17 March 1955.