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Journal of Nutrition Vol. 56 No. 4 August 1955, pp. 447-454
Copyright © 1955 by American Society for Nutrition
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The Enhancement of the Toxicity of Sodium Fluoride in the Rat by High Dietary Fat1

Russell F. Miller and Paul H. Phillips

Department of Biochemistry, College of Agriculture, University of Wisconsin, Madison

1. Increasing the dietary fat from 5 to 15%, in a purified ration increased the growth-retarding effect of a diet which contained 0.1% of sodium fluoride. It was established further that the protein-energy relationship was not responsible for the retardation effect of high fat on rats fed sodium fluoride.
2. Dietary supplements of pantothenate, methionine or ascorbic acid, alone or in combination, did not alter the growth-retarding effect of added dietary fat when the ration contained 0.1% of sodium fluoride. Neither did the subcutaneous or intraperitoneal injection of ATP, pantothenate or cysteine, either singly or in combination, prevent the enhancing effects of added fat on the development of fluorosis in the rat.
3. Fifteen per cent of butter fat as well as 15% of cottonseed oil were equally effective in enhancing the toxic action of 0.1% of sodium fluoride in the ration of the rat. The enhancing effect of added dietary fat could not be attributed to the chain length of the component fatty acids of the fat fed.
4. In these experiments the feeding of increased levels of fat and diets containing 0.1% sodium fluoride caused an increased deposition of fluorine in the femurs.

1 Published with the approval of the Director of the Wisconsin Agricultural Experiment Station. Supported in part by a grant from the Aluminum Company of America, Pittsburgh, Pennsylvania, on behalf of itself and the Aluminum Laboratories Ltd., the American Smelting and Refining Co., the Kaiser Aluminum and Chemical Corporation, the Monsanto Chemical Co., the Reynolds Metal Co., the Tennessee Valley Authority, the U. S. Steel Corporation of Delaware, and Westvaco, Chemical Division of Food Machinery and Chemical Corp.

Manuscript received 28 January 1955.




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