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A Biochemical Basis for the Interrelationship of Pantothenic Acid and Methionine¹

Department of Biochemistry, School of Medicine University of Arkansas, Little Rock

Experiments were designed to determine the biochemical basis of the interrelationship of pantothenic acid and methionine. Sprague-Dawley rats were fed various levels of methionine with and without pantothenic acid. Guanidoacetic acid was administered to the rats by stomach tube. Dietary pantothenic acid or methionine did not significantly affect the extent of methylation of guanidoacetic acid. Liver coenzyme A levels were markedly reduced when the diet was deficient in both methionine and pantothenic acid. Supplementation of the diet with either of these nutrients significantly increased liver coenzyme A levels; however, both were necessary for maintenance of normal levels of the coenzyme.

Manuscript received 28 February 1955.