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Journal of Nutrition Vol. 56 No. 2 June 1955, pp. 231-251
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The Threonine Requirement of the Normal Infant1,2,

Six Figures

Edward L. Pratt, Selma E. Snyderman3, Mung W. Cheung4, Patricia Norton and L. Emmett Holt, Jr.

Department of Pediatrics, New York University College of Medicine, New York City

Arild E. Hansen and Theodore C. Panos

Department of Pediatrics, University of Texas, Galveston

In studies designed to evaluate the threonine requirement of normal infants a synthetic diet was employed which provided nitrogen in the form of a mixture of 18 essential and non-essential amino acids, all as the natural L-isomers. It was found that infants would gain weight normally and exhibit every sign of health on such a diet, although a somewhat higher than average caloric intake was at times required.

By graded reduction of the threonine intake, threonine being replaced by glycine, the minimum threonine requirement was determined. This was found to be approximately 60 mg per kilogram per day for infants between one and 6 months of age.

A deficiency of threonine was associated with failure to gain weight and with impaired retention of nitrogen. There was increased loss of nitrogen in the urine, but no increased amino aciduria. Certain changes in the amino acid excretion pattern were observed, notably a decreased threonine excretion.

1 This work was supported in part by the U. S. Department of Agriculture under Contract A-1s-30942; the opinions expressed in this report are those of the authors and do not necessarily reflect those of the Department.

2 A preliminary report of this work was published in Federation Proceedings 12: 429, 1953 and in the Transactions of the American Pediatric Society, Am. J. Dis. Child., 86: 324, 1953.

3 H. R. Scheider Research Fellow, New York University.

4 Playtex Park Research Fellow, New York University.

Manuscript received 29 November 1954.




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