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Fatty Liver of Portal Type: Effects of Choline, Methionine, and Vitamin B₁₂^1,2,

School of Public Health, and Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, N. Y.

Choline and vitamin B₁₂ failed to prevent accumulation of excess hepatic lipid in the portal areas of rats fed diets containing either corn meal, cassava or rice as the only source of protein.

DL-methionine (0.5%) not only failed to prevent lipid accumulation in the livers, but in the instance of males on the corn meal diet had a tendency to increase the fat still further. Higher levels of methionine (1, 1.5 and 2%) added to the corn meal diet progressively reduced hepatic lipids, and at a 2% level, methionine caused normal hepatic lipid levels. At these higher levels, however, growth was correspondingly inhibited.

Determination of iodine number and cholesterol content revealed no significant differences between hepatic lipids deposited in the portal areas on corn diets or central areas on a choline-deficient diet with casein as the source of protein.

² Preliminary report of portions of this study were presented before the American Institute of Nutrition, Atlantic City, April 1954.

Manuscript received 18 November 1954.