QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Marsh, M. E. Articles by Rinehart, J. F. Search for Related Content PubMed PubMed Citation Articles by Marsh, M. E. Articles by Rinehart, J. F.

The Relationship Between Pyridoxine Ingestion and Transaminase Activity

I. Blood Hemolysates^1,2,

Six Figures

Department of Pathology, University of California School of Medicine, San Francisco

The method of Tonhazy et al. for the estimation of aspartic-glutamic transaminase has been adapted to the measurement of the enzyme in whole blood.

A study was made of the transaminase and vitamin B₆ levels of the blood of monkeys receiving graded doses of pyridoxine hydrochloride and also of humans receiving extradietary supplements of pyridoxine hydrochloride.

In both monkeys and man, increasing the intake of pyridoxine resulted in significant increases in the blood level of the transaminase and of the vitamin B₆. Reductions in the pyridoxine intake were followed by a lowering of the blood concentration of both factors. The changes in the level of transaminase were often more gradual, however, than were those of vitamin B₆. The time required to reduce the levels to a minimum after withdrawal of all pyridoxine or to the initial levels after the supplemental dosage was discontinued seemed to be dependent to some extent upon the duration of the period of the increased intake.

² Presented before the Federation of American Societies for Experimental Biology, April 16, 1954.

Manuscript received 19 November 1954.