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The Effect of Fat Level of the Diet on General Nutrition

XV. Comparison of the Protective Effect of Linoleic Acid and Linolenic Acid Against Multiple Sublethal Doses of X-Irradiation in the Rat^1,2,

Department of Biochemistry and Nutrition, School of Medicine, University of Southern California, Los Angeles

The ability of linoleic acid to protect animals against x-irradiation injury has again been confirmed. Linolenic acid exhibits only a slight and insignificant protective effect against x-irradiation in male rats as judged by average survival time and by the extent of mortality at the termination of the experiment. However, when linolenate is administered at a minimum level (10 mg) together with a minimum level of linoleate (10 mg), a marked increase in protective action against x-irradiation is obtained which suggests that a synergism exists. This behavior is similar to the action on growth of linolenate alone and with linoleate observed earlier in rats on fat-free diets. It is again suggested that linoleate is required to initiate the action of linolenate.

² Contribution no. 383 of the Department of Biochemistry and Nutrition, University of Southern California.

Manuscript received 3 November 1954.