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Effect of Genistin on Reproduction of the Mouse1,2,

M. W. Carter, Gennard Matrone and W. W. G. Smart, Jr.

Animal Nutrition Section of Department of Animal Industry, North Carolina Agricultural Experiment Station, Raleigh

A study was conducted to determine the effects of soybean oil meal and of genistin extracted from it on growth and reproduction of the mouse. Growth of the mice from three to 7 weeks of age was not affected by the treatments used in this experiment. Both commercial soybean oil meal and isolated genistin significantly lowered the age at which the vaginas of immature mice opened. The principal effect on reproduction of 0.2% genistin in the diet was a decrease in the number of litters born, whereas litter size was not affected. The effect of commercial soybean oil meal (80% of the diet) on the number of litters born was not statistically significant but the number of litters obtained was less than that from the group of females on the control diet.


1 Published with the approval of the Director of Research as Paper no. 600 of the Journal Series. The data were taken from a thesis submitted by the senior author in partial fulfillment of the requirements for the Master of Science degree.

2 Supported in part by Tennessee Valley Authority, Knoxville, Tennessee.

Manuscript received 1 November 1954.





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