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Journal of Nutrition Vol. 55 No. 4 April 1955, pp. 611-621
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Hemoglobin Concentration, Thyroid Weight and Growth Rate in Rats During Minimum Fluoride Ingestion1

Aina M. Auskaps and James H. Shaw

Harvard School of Dental Medicine, Boston, Massachusetts

When fluoride was administered in the drinking water to rats as sodium fluoride at levels of 1, 5 and 20 ppm, there was normal growth and reproductivity, no depression of hemoglobin formation, no detectable fluoride uptake by thyroid glands, no hypertrophic changes in the thyroid and no decrease in animal resistance to a severe respiratory infectious disease.

Dental caries incidence was significantly reduced when 20 ppm of fluoride were ingested in the drinking water.

1 This investigation was supported to a large extent by grants-in-aid from the Nutrition Foundation, Inc., New York, N. Y.; the Office of Naval Research; and the Division of Research Grants and Fellowships, U. S. Public Health Service.

Manuscript received 5 November 1954.




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