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The Use of Depleted Rats for Investigations of Vitamin B₁₂ and Unidentified Factors

Nutrition Research Laboratories, Ralston Purina Company, St. Louis, Missouri

Depleted weanling rats from breeder females which received a vegetable-protein ration during gestation and lactation were used for investigations of vitamin B₁₂ and unidentified factors.

The weanling rats responded to vitamin B_12a and to graded levels of vitamin B₁₂ but not to pseudovitamin B₁₂. The addition of unidentified factors produced more than twice as much gain as was observed with 13.75 µg of vitamin B₁₂/kg.

With vitamin B₁₂ in the ration, dried whole liver, dried liver extract, fish solubles and dried whey produced greater gains than fish meal and fermentation solubles. Antibiotics, 3-nitro, 4-hydroxyphenylarsonic acid, malt sprouts, liver residue, lyxoflavin and mucin were inactive as sources of unidentified factors. The response with grass juice factor and orotic acid were small and of doubtful significance.

Manuscript received 16 August 1954.