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The Nature of the Creatinuria of Nutritional Muscular Dystrophy in the Rat¹

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Department of Biochemistry, School of Medicine, University of Arkansas, Little Rock

Nutritional muscular dystrophy was induced in rats by the feeding of a diet deficient in both vitamins E and B₆. Other groups of rats received this basal diet supplemented with vitamins E and B₆ singly and in combination. The rats were injected with either sodium C¹⁴ formate or C¹⁴ methyl-labeled choline and the specific activities of excreted creatinine and creatine were determined. Results were similar with both of the labeled creatine presursors. The animals deficient in both vitamins E and B₆ excreted large amounts of creatine. The specific activity of creatinine excreted following the injection of either radioactive precursor was elevated in the rats deficient in both vitamins. The specific activity of creatine excreted by the doubly deficient animals following the administration of sodium C¹⁴ formate exhibited the same specific activity as did the creatinine. It is concluded that the creatinuria which accompanies nutritional muscular dystrophy in the rat is the result of an inability of the muscle to retain creatine after its incorporation.

Manuscript received 12 August 1954.