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Studies on the Effect of Sodium Bisulfite on the Stability of Vitamin E¹

Agricultural Experiment Station and School of Nutrition, Cornell University, Ithaca, New York

Evidence has been obtained in studies with chicks that the inclusion of sodium bisulfite in a purified diet containing iron, manganese and copper salts accelerates the development of oxidative rancidity in unsaturated fat and increases the incidence and severity of vitamin E deficiency. Both encephalomalacia and exudative diathesis were observed. Encephalomalacia appeared to be the more acute form and exudative diathesis the more chronic form of vitamin E deficiency.

The results showed, in agreement with evidence reported by other workers, that actively developing oxidative rancidity in unsaturated fat is directly concerned in the destruction of vitamin E and indicated that one of the functions of the vitaman is the maintenance of the integrity of unsaturated fatty acid molecules.

² Present address: Research Division, Kasco Mills, Waverly, New York.

³ Now in Military Service.

Manuscript received 12 July 1954.

This article has been cited by other articles:

				B. CENTURY, M. K. HORWITT, and P. BAILEY Lipid Factors in the Production of Enephalomalacia in the Chick Arch Gen Psychiatry, October 1, 1959; 1(4): 420 - 424. [Abstract] [PDF]