Journal of Nutrition Animal Diets/Enrichment Products...

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 55 No. 1 January 1955, pp. 35-61
Copyright
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krehl, W. A.
Right arrow Articles by Whedon, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krehl, W. A.
Right arrow Articles by Whedon, A. D.

Non-Deleterious Effects of Polyoxyethylene Esters in the Nutrition of Rats and Cats1

W. A. Krehl, George R. Cowgill and A. D. Whedon

Department of Biochemistry, Yale Nutrition Laboratory, Yale University School of Medicine, New Haven, Connectiout

Polyoxyethylene mono- and di-stearates, mono- and dioleates, and mono- and di-laurates were fed to groups of rats at a level of 6% of the diet. Polyoxyethylene-8-monostearate (Myrj 45) was fed to rats and cats at levels of 10% and 20% of the diet, respectively. The polyoxyethylene moiety of Myrj 45 was fed to rats at a dietary level of 6%. These experiments were of the long-term type extending over one and a half years for the rats and over one year for the cats.

At the end of the experiment the animals were autopsied and the spleen, liver, lungs, testes, thyroid, adrenal, kidney, intestine, urinary bladder and heart were removed for preparation of tissue sections and histological examination for possible evidence of pathology.

There were no significant differences between the groups fed the control diets and those given the same diets supplemented with these various polyoxyethylene esters.

It is concluded that under the experimental conditions employed, no reasonable doubt exists concerning the safety of the polyoxyethylene stearates even when fed at levels up to 20% of the diet. The low palatability of these compounds together with the fact that the polyoxyethylene moiety has no nutritive value renders impractical their usefulness at anything but low levels.

1 The authors are indebted to the Atlas Powder Company, Wilmington, Delaware, for a grant in aid to support this work and for the polyoxyethylene compounds used in this study.

Manuscript received 30 July 1954.




Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]