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Nicotinic Acid Metabolism in the Rhesus Monkey

Department of Physiology, Presidency College, Calcutta, India

Nicotinic acid and amide, nicotinuric acid, NMN, 6-pyridone, trigonelline and quinolinic acid were estimated in the urine of rhesus monkeys after they were fed sulfaguanidine, nicotinic acid and DL-tryptophan.

Sulfaguanidine produced only a slight diminution in the excretion of NMN. The excretions of other metabolites of nicotinic acid remained unchanged. Nicotinic acid produced an increased elimination of NMN, 6-pyridone and nicotinuric acid. The excretions of 6-pyridone and NMN increased considerably after the administration of tryptophan. Quinolinic acid excretion increased after the administration of both nicotinic acid and tryptophan.

NMN and 6-pyridone are the principal metabolic end products of nicotinic acid in the monkey. These animals can also convert tryptophan into nicotinic acid. When the diet contains sufficient nicotinic acid the dietary tryptophan is converted principally into quinolinic acid and in other cases tryptophan is converted into both quinolinic acid and nicotinic acid.