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Dietary Protein and Tumor-Host Relationship in the Rat^{1, 2,}

Bureau of Biological Research and Department of Physiology and Biochemistry, Rutgers University, New Brunswick, New Jersey

The time for the establishment of a transplanted sarcoma in the rat was at a minimum in animals fed 12% of casein. Supplementing 12% of casein with 0.67% of DL-methionine, or increasing the casein content of the diet to 25 or 35% lengthened this induction period. However, the rate of growth of the tumor after it was established was the same on all diets.

Feeding the methionine-supplemented diet or the high-casein diet favored the development of the carcass of the tumor-bearing rat, thereby reducing the depleting effect of the growing tumor.

N, N', N''-triethylenephosphoramide reduced the development of both tumor and carcass; food utilization by the carcass was also reduced in the presence of this drug.

Supplementing 12% of casein with methionine, or feeding high protein diets, favored the development of the carcass in the presence of TEPA, resulting in a more favorable condition for long survival time and regression of the tumor.

² Presented before the meeting of the American Chemical Society, Kansas City, Missouri. April, 1954.

Manuscript received 25 June 1954.