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Journal of Nutrition Vol. 54 No. 3 November 1954, pp. 417-426
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An Unidentified Chick-Growth Factor Found in Litter1

R. L. Jacobs, J. F. Elam, Jean Fowler and J. R. Couch

Departments of Biochemistry and Nutrition and Poultry Husbandry, Texas Agricultural and Mechanical College System, College Station

A hitherto unrecognized chick-growth factor present in litter is reported. The factor is thermostable and probably produced by microbial fermentation. Data from two separate experiments are reported. The factor gave a significant growth response when added to an all-vegetable protein diet adequate with respect to the known vitamins. The factor gave a growth response comparable to that produced by fish solubles or a combination of 4 antibiotics and produced an additive effect when fed with either of the latter supplements.

It is concluded that the litter factor is not an antibiotic and differs from the growth factor present in fish solubles.

1 The work was supported in part by grants-in-aid from Lederle Laboratories, Pearl River, New York; Merck and Company, Rahway, New Jersey; Philip R. Park, San Pedro, California; Commercial Solvents Corporation, Terre Haute, Indiana; and the Williams-Waterman Fund for the Combat of Dietary Diseases, New York, New York.

The stabilized vitamin A supplement was supplied by Stabilized Vitamins, Inc., Brooklyn, New York. The riboflavin, calcium pantothenate, niacin and choline chloride were supplied by Merck and Company, Rahway, New Jersey.

Manuscript received 5 June 1954.




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